CLINICAL TRIALS AND OBSERVATIONS The impact of prophylactic fresh-frozen plasma and cryoprecipitate on the incidence of central nervous system thrombosis and hemorrhage in children with acute lymphoblastic leukemia receiving asparaginase
نویسندگان
چکیده
1Department of Pediatrics, Dalhousie University and Isaak Walton Killam Health Centre, Halifax, NS; 2Department of Pediatrics, University of British Columbia, BC Children’s Hospital, Vancouver, BC; 3Division of Hematology/Oncology, Dalhousie University and Izaak Walton Killam Health Centre, Halifax, NS; and 4Division of Hematology/Oncology, University of British Columbia, BC Children’s Hospital, Vancouver, BC
منابع مشابه
CLINICAL TRIALS AND OBSERVATIONS Dexamethasone exposure and asparaginase antibodies affect relapse risk in acute lymphoblastic leukemia
We have previously hypothesized that higher systemic exposure to asparaginase may cause increased exposure to dexamethasone, both critical chemotherapeutic agents for acute lymphoblastic leukemia. Whether interpatient pharmacokinetic differences in dexamethasone contribute to relapse risk has never been studied. The impact of plasma clearance of dexamethasone and anti–asparaginase antibody leve...
متن کاملCLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Comparison of Escherichia coli–asparaginase with Erwinia-asparaginase in the treatment of childhood lymphoid malignancies: results of a randomized European Organisation for Research and Treatment of Cancer—Children’s Leukemia Group phase 3 trial
Asparaginase is an enzyme used in the treatment of acute lymphoblastic leukemia and lymphoblastic lymphoma in children. It has minimal bone marrow toxicity. Its major side effects are anaphylaxis, pancreatitis, diabetes, coagulation abnormalities, and thrombosis, especially intracranial. It is derived from 2 different sources: Escherichia coli and Erwinia chrysanthemi. Nonrandomized clinical st...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Results of a randomized international study of high-risk central nervous system B non-Hodgkin lymphoma and B acute lymphoblastic leukemia in children and adolescents
Results of a randomized international study of high-risk central nervous system B non-Hodgkin lymphoma and B acute lymphoblastic leukemia in children and adolescents Mitchell S. Cairo,1 Mary Gerrard,2 Richard Sposto,3 Anne Auperin,4 C. Ross Pinkerton,5 Jean Michon,6 Claire Weston,7 Sherrie L. Perkins,8 Martine Raphael,9 Keith McCarthy,10 and Catherine Patte,4 on behalf of the FAB LMB96 Internat...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Pharmacokinetics, pharmacodynamics, efficacy, and safety of a new recombinant asparaginase preparation in children with previously untreated acute lymphoblastic leukemia: a randomized phase 2 clinical trial
The pharmacokinetics, pharmacodynamics, efficacy, and safety of a new recombinant Escherichia coli–asparaginase preparation was compared with Asparaginase medac. Thirty-two children with acute lymphoblastic leukemia were randomized to receive one of both agents at a dose of 5000 U/m2 every 3 days, for a total of 8 doses during induction treatment. The serum activity-time profile after the first...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Up-regulation of asparagine synthetase expression is not linked to the clinical response to L-asparaginase in pediatric acute lymphoblastic leukemia
L-asparaginase (L-Asp) is an effective drug for treatment of children with acute lymphoblastic leukemia (ALL). The effectiveness is generally thought to result from a rapid depletion of asparagine in serum and cells. Asparagine synthetase (AS) opposes the action of L-Asp by resynthesis of asparagine. In vitro, resistance to L-Asp has been associated with upregulation of AS mRNA expression. We m...
متن کامل